Mittwoch, 3. Juli 2013
Science: Exercise and coronary heart disease risk markers in SouthAsians
Purpose: South Asians have a higher than average risk of coronary heart disease. The reasons for this are unclear but physical inactivity and/or poor responsiveness to exercise may play a role. This study compared the effect of prior exercise on postprandial triacylglycerol (TAG), glucose, insulin, interleukin-6 (IL-6) and soluble intercellular adhesion molecule-1 (sICAM-1) concentrations in South Asian and European men.
Methods: Ten healthy South Asian men (i.e. nine Indian men and one Pakistani man) and 10 healthy European men aged 20 to 28 years completed two, 2-day trials (exercise and control) in a randomisedcrossover design. On the afternoon of day 1 of the exercise trial, participants ran on a treadmill for 60 minutes at approximately 70% of maximal oxygen uptake. Participants rested on day 1 of the control trial. On day 2 of both trials participants rested and consumed high fat (57% of energy content) test meals for breakfast (0 h) and lunch (4 h). Fourteen venous blood samples were collected from a cannula between 0 h and 9 h for metabolic measurements.
Results: Three-way ANOVA identified higher (P < 0.05) postprandial TAG and insulin concentrations in South Asian versus European men. Exercise lowered postprandial TAG and IL-6 and elevated sICAM-1 concentrations. An interaction effect indicated a greater decrease (22 versus 10%) in TAG area under the concentration versus time curve after exercise in South Asian than European men.
Conclusions: Postprandial TAG and insulin responses to high fat meals were elevated in these South Asian men but acute exercise was equally if not more effective for reducing postprandial lipemia in South Asian than in European men.